γ-Synuclein as a Cancer Biomarker: Viewpoint and New Approaches
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چکیده
منابع مشابه
γ-Synuclein as a Cancer Biomarker: Viewpoint and New Approaches
Synucleinopathies are complex diseases that progress through several steps, and increasing evidence suggests that an early diagnosis might significantly increase the efficacy of the treatment. A member of the synuclein family, α-synuclein is associated with neurodegenerative diseases, whereas another member, γ-synuclein is implicated predominantly in various forms of cancer. Synucleins can be p...
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PURPOSE Previous studies have described gamma-synuclein as a protein highly expressed in retinal ganglion cells (RGCs), and a loss of RGCs correlates with a downregulation of gamma-synuclein gene expression in glaucoma. Here we asked whether gamma-synuclein expression in the retina can be considered a specific marker of RGCs. METHODS gamma-Synuclein expression was examined with immunohistoche...
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INTRODUCTION Several neurodegenerative diseases are classified as proteopathies as they are associated with the aggregation of misfolded proteins. Synucleinopathies are a group of neurodegenerative disorders associated with abnormal deposition of synucleins. α-Synucleinopathies include Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Recently accumulation of another ...
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ژورنال
عنوان ژورنال: Oncomedicine
سال: 2016
ISSN: 2206-6349
DOI: 10.7150/oncm.16748